CM272 is a novel and first-class double reversible inhibitor of G9a (GLP) and DNMTs, with IC50 values of 8 nM, 382 nM, 85 nM, 1200 nM, and 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, and GLP, respectively. CM272 extended survival time in vivo models of hematological malignancies by at least partially inducing immunogenic cell death.

Brand: BCM

 

Boiling Point: 631.9±55.0 °C(Predicted)

 

pKa: 10.09±0.20(Predicted)

 

GHS: GHS07

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5  

 

InChIKey: RLQLKZTYUYIWDB-UHFFFAOYSA-N  

 

InChI: InChI=1S/C28H38N4O3/c1-20-7-8-26(35-20)25-18-23(29-21-9-14-31(2)15-10-21)22-17-27(33-3)28(19-24(22)30-25)34-16-6-13-32-11-4-5-12-32/h7-8,17-19,21H,4-6,9-16H2,1-3H3,(H,29,30)

 

Attribute
[Chem Name]	6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine
[Synonym]	CM-272; CM272; CM 272
[CAS No.]	1846570-31-7
[MDL No.]	MFCD31812316
[Formula]	C28H38N4O3
[Molecular]	478.63
[Form]	A crystalline solid
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

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