BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor that inhibits TNF-α-induced phosphorylation of IκBα with an IC50 of 10 μM in tumor cells. BAY 11-7082 inhibited ubiquitin-specific protease USP7 and USP21 with corresponding IC50 values of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.

 

Brand: BCM

 

Melting Point: 133-135℃

 

Boiling Point: 397.6±42.0 °C(Predicted)

 

Signaling Pathways: Ubiquitination; Autophagy; Others; Apoptosis; DNA Damage/DNA Repair; NF-κB; Cell Cycle/Checkpoint

 

GHS: GHS07

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N  

 

InChIKey: DOEWDSDBFRHVAP-KRXBUXKQSA-N  

 

InChI: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

 

Attribute
[Chem Name]	(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile
[Synonym]	BAY 11-7082; BAY11-7082; BAY 11-7821； (E)-3-tosylacrylonitrile
[CAS No.]	19542-67-7
[MDL No.]	MFCD00712162
[Formula]	C10H9NO2S
[Molecular]	207.25
[Form]	White solid
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C

Goods Tag