SC-514 (GK 01140) is an orally effective, ATP-competitive IKK-2 inhibitor with an IC50 of 3-12 μM that inhibits NF-κB-dependent gene expression and does not inhibit other IKK isomers or other serine-threonine and tyrosine kinases.

 

Brand: BCM

 

Signaling Pathways: Proteases/Proteasome; MAPK; NF-κB; Cell Cycle/Checkpoint; Chromatin/Epigenetic

 

Melting Point: 209-211°C

 

GHS: GHS07

 

Solubility: Soluble in DMSO. Insoluble in Ethanol; insoluble in Water.

 

Isomeric SMILES: C1=CSC=C1C2=CC(=C(S2)C(=O)N)N  

 

InChIKey: BMUACLADCKCNKZ-UHFFFAOYSA-N  

 

InChI: InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12)

 

Attribute
[Chem Name]	3-amino-5-thiophen-3-ylthiophene-2-carboxamide
[Synonym]	SC-514; GK 01140; GK-01140
[CAS No.]	354812-17-2
[MDL No.]	MFCD00206459
[Formula]	C9H8N2OS2
[Molecular]	224.3
[Form]	White to light brown powder
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

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