MK-2048 is a potent integrase(IN) and INR263K inhibitor with IC50 of 2.6 nM and 1.5 nM, respectively.

 

Brand: BCM

 

Target: Integrase (R263K):1.5 nM, Integrase:2.6 nM

 

Signaling Pathways: Proteases/Proteasome; Microbiology/Virology

 

Isomeric SMILES: CCN1C[C@@H](N2C3=C(C(=C2C1=O)O)C(=O)N(N=C3C(=O)NC)CC4=CC(=C(C=C4)F)Cl)C  

 

InChIKey: JSRREMIKIHJGAA-JTQLQIEISA-N  

 

InChI: InChI=1S/C21H21ClFN5O4/c1-4-26-8-10(2)28-16-14(18(29)17(28)21(26)32)20(31)27(25-15(16)19(30)24-3)9-11-5-6-13(23)12(22)7-11/h5-7,10,29H,4,8-9H2,1-3H3,(H,24,30)/t10-/m0/s1

 

Attribute
[Chem Name]	(13S)-5-[(3-chloro-4-fluorophenyl)methyl]-11-ethyl-8-hydroxy-N,13-dimethyl-6,10-dioxo-1,4,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2(7),3,8-triene-3-carboxamide
[Synonym]	MK-2048; MK2048; MK 2048
[CAS No.]	869901-69-9
[Formula]	C21H21ClFN5O4
[Molecular]	461.87
[Form]	Powder
[Storage]	Powder: -20°C for 3 years. In solvent: -80°C for 2 years

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