EGFR inhibitor is a 4, 6-disubstitutable pyrimidine compound that penetrates cells and is a highly selective inhibitor of EGFR kinase with IC50 of 21 nM. EGFR inhibitor can directly depolymerize microtubules, which can be used as a chemical probe to study EGFR pathway and microtubule kinetics.

Brand: BCM

 

Target: EGFR (WT):21 nM (IC50);EGFRL858R:63 nM (IC50);EGFRL861Q:4 nM (IC50);HER4:7640 nM (IC50)

 

pKa: 14.50±0.70(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: C1CC1C(=O)NC2=CC=CC(=C2)NC3=NC=NC(=C3)NC4=CC=CC(=C4)C(F)(F)F  

 

InChIKey: YOHYSYJDKVYCJI-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(9-14)27-18-11-19(26-12-25-18)28-16-5-2-6-17(10-16)29-20(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,29,30)(H2,25,26,27,28)

 

Attribute
[Chem Name]	N-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide
[Synonym]	EGFR Inhibitor; EGFR-IN-12
[CAS No.]	879127-07-8
[MDL No.]	MFCD13191284
[Formula]	C21H18F3N5O
[Molecular]	413.4
[Form]	Crystalline solid
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

Goods Tag