Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with an IC50 of 3.2 nM, 5.3 nM, and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib induced apoptosis and G1 cell cycle arrest. Phase 2.

 

Brand: BCM

 

Melting Point: 187 - 190° C

 

pKa: 5.35±0.30(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insolube in Ethanol.

 

Isomeric SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C  

 

InChIKey: LPFWVDIFUFFKJU-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

 

Attribute
[Chem Name]	1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
[Synonym]	Poziotinib; HM781-36B
[CAS No.]	1092364-38-9
[MDL No.]	MFCD28044290
[Formula]	C23H21Cl2FN4O3
[Molecular]	491.34
[Form]	White to Pale Beige Solid
[Storage]	Keep in dark place. Sealed in dry, 2-8°C

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