APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell cycle arrest and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also a KLF4 (ruppel-like factor 4) inducer.

 

Brand: BCM

 

Boiling Point: 718.8±70.0 °C at 760 mmHg

 

Flashing Point: 388.5±35.7 °C

 

pKa: 7.75±0.50(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Ethanol; insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6  

 

InChIKey: NIRXBXIPHUTNNI-UHFFFAOYSA-N  

 

InChI: InChI=1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)

 

Attribute
[Chem Name]	2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
[Synonym]	APTO-253; LOR-253; LT-253
[CAS No.]	916151-99-0
[MDL No.]	MFCD25976826
[Formula]	C22H14FN5
[Molecular]	367.38
[Form]	A solid
[Storage]	Sealed in dry, 2-8°C

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