MRT-10 inhibited the ShhN signaling pathway in a dose-dependent manner in Shh-light2 cells with an IC50 of 0.64 μM, demonstrating the ability to eliminate Smo constitutive activity.

 

Brand: BCM

 

Signaling Pathways: GPCR/G Protein; Stem Cells

 

Target: Hedgehog/Smoothened

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)NC(=S)NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3  

 

InChIKey: KVQVEZQDNHMQJV-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H23N3O5S/c1-30-19-12-16(13-20(31-2)21(19)32-3)23(29)27-24(33)26-18-11-7-10-17(14-18)25-22(28)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,25,28)(H2,26,27,29,33)

 

Attribute
[Chem Name]	N-[(3-benzamidophenyl)carbamothioyl]-3,4,5-trimethoxybenzamide
[Synonym]	MRT-10
[CAS No.]	330829-30-6
[MDL No.]	MFCD02734587
[Formula]	C24H23N3O5S
[Molecular]	465.52
[Form]	White to tan powder
[Storage]	Sealed in dry, 2-8°C

Goods Tag