Anisomycin (Flagecidin, Wuningmeisu C) is an antimicrobial antibiotic derived from Streptomyces griseolus that inhibits protein synthesis and is also a JNK activator. Anisomycin promotes autophagy and apoptosis.

 

Brand: BCM

 

Target: Apoptosis; DNA/RNA Synthesis; JNK; Antibiotic; Antibacterial

 

Signaling Pathways: Cell Cycle/Checkpoint; Microbiology/Virology; MAPK; DNA Damage/DNA Repair; Apoptosis

 

Boiling Point: 398.7℃ at 760 mmHg

 

Flashing Point: 87°C

 

Specific Rotation: D23 -30° (methanol)

 

Sensitivity: Sensitive to heat and moisture

 

pKa: 7.9(at 25℃)

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath); soluble in Ethanol (warmed with 50ºC water bath). Insoluble in Water.

 

GHS: GHS06

 

Isomeric SMILES: CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O  

 

InChIKey: YKJYKKNCCRKFSL-RDBSUJKOSA-N  

 

InChI: InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1 

 

Attribute
[Chem Name]	[(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate
[Synonym]	Anisomycin; Flagecidin; Wuningmeisu C
[CAS No.]	22862-76-6
[EINECS]	245-269-7
[MDL No.]	MFCD00077650
[Formula]	C14H19NO4
[Molecular]	265.3
[Form]	White solid
[Storage]	Inert atmosphere. Store in freezer, under -20°C

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