1-NM-PP1 (PP1 Analog II, 1NM-PP1, analogue 9) is a potent inhibitor of SRC-family kinases with IC50 values of 4.3 nM and 3.2 nM for v-Src-as1 and c-Fyn-as1, respectively. 1-NM-PP1 also inhibited CDK2-as1, CAMKII-as1, and c-Abl-as2 with IC50 values of 5.0 nM, 8.0 nM, and 120 nM, respectively.

 

Brand: BCM

 

Melting Point: 175-176°C

 

Boiling Point: 545.7±45.0 °C(Predicted)

 

Target: permeable protein kinase D (PKD):0.398 μM

 

Signaling Pathways: Tyrosine Kinase/Adaptors; Angiogenesis; Metabolism; Cell Cycle/Checkpoint

 

pKa: 4.50±0.30(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07, GHS03

 

Isomeric SMILES: CC(C)(C)N1C2=NC=NC(=C2C(=N1)CC3=CC=CC4=CC=CC=C43)N  

 

InChIKey: GDQXJQSQYMMKRA-UHFFFAOYSA-N  

 

InChI: InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23)

 

Attribute
[Chem Name]	1-tert-butyl-3-(naphthalen-1-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine
[Synonym]	1-NM-PP1; PP1 Analog II; 1NM-PP1; analogue 9
[CAS No.]	221244-14-0
[MDL No.]	MFCD03425470
[Formula]	C20H21N5
[Molecular]	331.41
[Form]	White to beige solid
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

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