Elacridar (GF120918, GW120918, GG918, GW0918) is a potent P-gp (MDR-1) and BCRP inhibitor.

 

Brand: BCM

 

Target: P-gp; BCRP

 

Signaling Pathways: Membrane transporter/Ion channel; Neuroscience

 

Melting Point: 216-218°C

 

Boiling Point: 701.6±60.0 °C(Predicted)

 

pKa: 12.58±0.70(Predicted)

 

Solubility: DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC  

 

InChIKey: OSFCMRGOZNQUSW-UHFFFAOYSA-N  

 

InChI: InChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38) 

 

Attribute
[Chem Name]	N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide
[Synonym]	Elacridar; GF120918; GW120918; GG918; GW0918
[CAS No.]	143664-11-3
[EINECS]	1532714-185-1
[MDL No.]	MFCD00912604
[Formula]	C34H33N3O5
[Molecular]	563.64
[Form]	White to beige powder
[Storage]	Keep in dark place. Sealed in dry. Store in freezer, under -20°C

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