LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor that inhibits the Wnt signaling pathway with an IC50 of 0.4 nM in TM3 cells. Phase 1.

 

Brand: BCM

 

Target: Porcupine

 

Signaling Pathways: Stem Cells

 

Melting Point: 176 - 180°C

 

Boiling Point: 650.9±55.0 °C(Predicted)

 

pKa: 12.24±0.70(Predicted)

 

Solubility: Soluble in DMSO (warmed with 50ºC water bath). Insoluble in Water; insoluble in Ethanol.

 

Isomeric SMILES: CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4  

 

InChIKey: XXYGTCZJJLTAGH-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)

 

Attribute
[Chem Name]	2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
[Synonym]	LGK-974; NVP-LGK974; WNT974
[CAS No.]	1243244-14-5
[MDL No.]	MFCD27501026
[Formula]	C23H20N6O
[Molecular]	396.44
[Form]	White to Off-White Solid
[Storage]	Sealed in dry. Room Temperature

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