TAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE226 can block FAK and IGF-IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration-dependent decrease in cellular proliferation with an associated G(2) cell cycle arrest in every cell line and an increase in apoptosis in a cell-line-specific manner. TAE226 also decreased glioma cell adhesion, migration, and invasion through an artificial extracellular matrix.

 

Brand: BCM

 

Solubility: Soluble in DMSO. Insoluble in Water.

 

InChi Key: UYJNQQDJUOUFQJ-UHFFFAOYSA-N

 

Attribute
[CAS No.]	761437-28-9
[MDL No.]	MFCD12031516
[Formula]	C23H25ClN6O3
[Molecular]	468.94
[Chem Name]	2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
[Synonym]	NVPTAE226, NVP TAE226, NVP-TAE226, TAE226, TAE226, TAE 226
[Form]	White to light yellow solid powder

Goods Tag