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Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with an IC50 of 36 nM in LNCaP cells. Enzalutamide has been shown to promote autophagy.
Brand: BCM
Target: Androgen Receptor; Autophagy
Signaling Pathways: Autophagy; Endocrinology/Hormones
Melting Point: 198 - 200°C
pKa: 13.88±0.46(Predicted)
Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.
Isomeric SMILES: CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C
InChIKey: WXCXUHSOUPDCQV-UHFFFAOYSA-N
InChI: InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)
Attribute [CAS No.] 915087-33-1 [Formula] C21H16F4N4O2S [MDL No.] MFCD14155804 [Chem Name] 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N-methylbenzamide [Synonym] Enzalutamide; MDV3100 [Storage] Keep in dark place. Inert atmosphere. Room temperature [EINECS] 805-022-1 [Molecular] 464.44 [Form] White to off-white solid
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