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Ataluren (PTC124) selectively induces ribosomal transcription readthrough, but does not affect the normal stop codon. EC50 is 0.1μM in HEK293 cells, which can cure the family inherited diseases caused by nonsense mutations (such as CF caused by CFTR nonsense mutations). Phase 3.
Brand: BCM
Melting Point: 241 - 242°C
pKa: 3.58±0.10(Predicted)
Solubility: Soluble in DMSO. Insoluble in Water and Ethanol.
Attribute [Chem Name] Ataluren 3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid [CAS No.] 775304-57-9 [Formula] C15H9FN2O3 [Molecular] 284.24 [EINECS] 922-364-8 [Synonym] Ataluren(PTC124) [Storage] -20°C [MDL No.] MFCD09864996 [Form] White to off-white solid
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