PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC50 of 1.5 and 14 nmol/L, respectively.Potent, selective ATP-competitive, reversible FAK Inhibitor (IC 50 values are 1.5, 13, 30, 47 and 58 nM for FAK, PYK2, CDK2, CDK2 and CDK1 respectively). Downregulates AKT/mTOR and CAS activity. Induces apoptosis. Shows antitumor effects in vivo.

 

Brand: BCM

 

Melting Point: >204°C (dec.)

 

pKa: 13.66±0.20(Predicted)

 

Solubility: DMSO (Slightly), Methanol (Slightly)

 

InChi Key: MZDKLVOWGIOKTN-UHFFFAOYSA-N 

 

Attribute
[CAS No.]	717907-75-0
[Formula]	C21H20F3N7O3S
[Molecular]	507.49
[Chem Name]	N-Methyl-N-(3-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulfonamide
[Synonym]	PF-562271； PF562271； PF 562271
[Storage]	Hygroscopic, -20°C Freezer。 Under inert atmosphere
[MDL No.]	MFCD16038299
[Form]	White powder

Goods Tag