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Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFR-β, Kit, RET, and Raf-1. IC50 was 13 nM, 4.2 nM, 46 nM, 22 nM, respectively, in cell-free tests. 7 nM, 1.5 nM and 2.5 nM.
Brand: BCM
Melting Point: 206.0 ~ 210.0 °C
Boiling Point: 513.4±50.0 °C(Predicted)
pKa: 12.04±0.70(Predicted)
Solubility: Soluble in DMSO. Insoluble in Water.
InChi Key: ZFLJHSQHILSNCM-UHFFFAOYSA-N
Attribute [CAS No.] 755037-03-7 [Formula] C21H15ClF4N4O3 [Molecular] 482.83 [MDL No.] MFCD16038047 [Chem Name] 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide [Synonym] BAY 734506; BAY734506; BAY-734506; Regorafenib. trade name: Stivarg [Form] White powder
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