NVP-ADW742 (GSK 552602A) is an IGF-1R inhibitor with IC50 of 0.17 μM. The effect of NVP-AdW742 on IGF-1R is more than 16 times stronger than that on InsR. There is little activity against HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

 

Brand: BCM

 

Boiling Point: 677.5±55.0 °C(Predicted)     

 

pKa: 10.00±0.20(Predicted)

 

Solubility: DMSO：10  mg/mL  heat  (22  mM)，Water：<1  mg/mL  (<1  mM)，Ethanol：3  mg/mL  (6  mM)

 

Attribute
[Formula]	C28H31N5O
[Molecular]	453.59
[CAS No.]	475488-23-4
[Storage]	-20°C
[MDL No.]	MFCD16038913
[Form]	Crystalline solid
[Chem Name]	5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
[Synonym]	NVP-ADW742; GSK 552602A

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