Fasudil (HA-1077, AT-877) is a potent and selective Rho inhibitor (ROCK2, Ki=0.33 μM) with inhibitory activity against PKA, PKG, PKC and MLCK. Ki values were 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. Fasudil is also a calcium channel blocker.

 

Brand: BCM

 

Signaling Pathways: Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors

 

Boiling Point: 506.2ºC at 760 mmHg

 

Melting Point: 222 °C(dec.)

 

Flashing Point: 259.9ºC

 

Solubility: Soluble in DMSO; soluble in Water. Insoluble in Ethanol.

 

Isomeric SMILES: C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl  

 

InChIKey: LFVPBERIVUNMGV-UHFFFAOYSA-N  

 

InChI: InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

 

Attribute
[CAS No.]	105628-07-7
[Formula]	C14H18ClN3O2S
[Molecular]	327.84
[MDL No.]	MFCD00943198
[Chem Name]	5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
[Synonym]	Fasudil hydrochloride; HA-1077; AT-877
[EINECS]	805-833-0
[Form]	White solid
[Storage]	Keep in dark place. Inert atmosphere. Room temperature

Goods Tag