MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.

 

Brand: BCM

 

Boiling Point: 698.3±65.0 °C(Predicted)

 

pKa: 2.85±0.10(Predicted)

 

Solubility: ≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

 

InChi Key: UJEAABFSXKCSGI-UHFFFAOYSA-N

 

Attribute
[Chem Name]	MK 8245
[Synonym]	CS-0410; (5-{3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]isoxazol-5-yl}-2H-tetrazol-2-yl)acetic acid; (5-{3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]isoxazol-5-yl}tetrazol-2-yl)acetic acid; UNII-537E7QE8LX; MK8245;
[CAS No.]	1030612-90-8
[MDL No.]	MFCD20039622
[Formula]	C17H16BRFN6O4
[Molecular]	467.25
[Storage]	Sealed in dry. Store in freezer, under -20°C
[Form]	Solid

Goods Tag