Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells. Dansylcadaverine functions by marking the autophagosomes, which allows researchers to follow the molecular components of the process throμghout. It is known that the specificity of Dansylcadaverine towards mammalian autophagosomes is due to ion trapping throμgh the acidic compartments of autophagosomes. In addition, Dansylcadaverine has biological applications in measuring cardiac autophagic flux, studying Parkinson's disease, peritoneal ovarian tumor dissemination, and respiratory diseases. This fluorescent tag is preferred over other due to its specificity and simplicity in detecting autophagic vesicles, which requires a brief exposure to the compound compared to previous methods. 

 

Brand: BCM

 

Melting Point: 137-140 °C

 

Boiling Point: 505.5±60.0 °C(Predicted)

 

Solubility: Soluble in Methanol: 10 mg/mL

 

pKa: 11.96±0.50(Predicted)

 

InChi Key: MLEBFEHOJICQQS-UHFFFAOYSA-N

 

Biochemical Mechanism: The autofluorescent dye danyl cadramide or montane sulfonyl cadramide (MDC) is commonly used to monitor autophagy. Due to a combination of ion capture and specific interactions with membrane lipids, montane sulfonylnecrotamine preferentially accumulates in autophagic vesicles.

 

Attribute
[Chem Name]	Dansylcadaverine
[CAS No.]	10121-91-2
[EINECS]	233-326-9
[MDL No.]	MFCD00042704
[Formula]	C17H25N3O2S
[Storage]	−20°C
[Molecular]	335.46
[Form]	Yellow to yellowish green powder

Goods Tag