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Fludarabine (NSC 118218, FaraA, Fludarabinum) is an inhibitor of STAT1 activation in vascular smooth muscle cells, specifically reducing STAT1 protein levels (and mRNA levels), but not other STATs. It is also an inhibitor of DNA synthesis. Fludarabine can induce apoptosis.
Brand: BCM
Melting Point: 265-268°C
Specific Rotation: D25 +17 ±2.5° (c = 0.1 in ethanol)
Boiling Point: 747.3±70.0 °C(Predicted)
pKa: 13.05±0.70(Predicted)
Solubility: Soluble in DMSO. Insoluble in Ethanol; insoluble in Water.
Isomeric SMILES: C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)F)N
InChIKey: HBUBKKRHXORPQB-FJFJXFQQSA-N
InChI: InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1
Attribute [CAS No.] 21679-14-1 [Formula] C10H12FN5O4 [Molecular] 285.23200 [MDL No.] MFCD00132942 [Chem Name] (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol [Form] White to pale yellow solid powder [Storage] Inert atmosphere, 2-8°C [EINECS] 244-525-5 [Synonym] Fludarabine; NSC 118218; FaraA; Fludarabinum
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