PF-573228 is an ATP-competitive inhibitor of FAK, with IC50 of 4 nM in cell-free tests. The selectivity of PF-573228 for FAK is 50 to 250 times higher than that for Pyk2, CDK1/7 and GSK-3β.

 

Brand: BCM

 

Melting Point: >242°C (dec.)

 

pKa: 14.30±0.20(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water.

 

InChIKey: HESLKTSGTIBHJU-UHFFFAOYSA-N

 

Attribute
[CAS No.]	869288-64-2
[Formula]	C22H20F3N5O3S
[Molecular]	491.492
[Chem Name]	3,4-Dihydro-6-[[4-[[[3-(Methylsulfonyl)phenyl]Methyl]aMino]-5-(trifluoroMethyl)-2-pyriMidinyl]aMino]-2(1H)-quinolinone
[MDL No.]	MFCD11519967
[Synonym]	PF-573228; PF573228; PF 573228
[Form]	White to off-white powder
[Storage]	2-8 °C

Goods Tag