R406 is an effective Syk inhibitor with IC50 of 41 nM in cell-free test. It has strong inhibitory effect on Syk, but does not inhibit Lyn. Its effect on Flt3 is 5 times lower than that of Syk. Phase 1.

 

Brand: BCM

 

Solubility: ≥31.45 mg/mL in DMSO; insoluble in H2O; ≥14.95 mg/mL in EtOH with ultrasonic

 

Attribute
[CAS No.]	841290-81-1
[Formula]	C22H23FN6O5.C6H6O3S
[Molecular]	628.6286632
[MDL No.]	MFCD18385012
[Chem Name]	2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one,6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-, monobenzenesulfonate
[Synonym]	CS-0229; R406; R406 Benzenesulfonate
[Form]	Solid

Goods Tag