Ponatinib (AP24534) is a novel and effective multi-target inhibitor that acts on Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 values of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively, in cell-free trials.

 

Brand: BCM

 

Melting Point: >175°C (dec.)

 

pKa: 12.99±0.70(Predicted)

 

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).

 

Stability: Stable for 2 years from date? of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

 

GHS: GHS06, GHS08

 

Isomeric SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5  

 

InChIKey: PHXJVRSECIGDHY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)  

 

Attribute
[CAS No.]	943319-70-8
[Formula]	C29H27F3N6O
[Molecular]	532.5595
[Chem Name]	3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
[Synonym]	AP24534; Ponatinib
[Storage]	Sealed in dry,Store in freezer, under -20°C
[EINECS]	1308068-626-2
[MDL No.]	MFCD17215203
[Form]	Yellow powder

Goods Tag