Fruquintinib is a small molecule inhibitor with strong potency and high selectivity against VEGFR family. It inhibits VEGFR 1, 2, 3, with IC50 values of 33 nM, 35 nM and 0.5 nM, respectively and shows only weak inhibition of RET, FGFR-1 and c-kit kinases.

 

Brand: BCM

 

Boiling Point: 600.5±55.0 °C(Predicted)

 

pKa: 14.35±0.46(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water.

 

Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

 

GHS: GHS07

 

Signaling Pathways: Angiogenesis; Tyrosine Kinase/Adaptors

 

Isomeric SMILES: CC1=C(C2=C(O1)C=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(=O)NC  

 

InChIKey: BALLNEJQLSTPIO-UHFFFAOYSA-N  

 

InChI: InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)

 

Attribute
[CAS No.]	1194506-26-7
[Formula]	C21H19N3O5
[Molecular]	393.39
[Storage]	Sealed in dry. Store in freezer, under -20°C
[MDL No.]	MFCD28502149
[Form]	White solid
[Chem Name]	6-(6,7-dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide
[Synonym]	Fruquintinib; HMPL-013

Goods Tag