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ENMD-2076 selectively acts on Aurora A and VEGFR(Flt3) with an IC50 of 14 nM and 1.86 nM, respectively. The selectivity of EnmD-2076 on Aurora A is 25 times higher than that on Aurora B, and the selectivity on VEGFR2/KDR and VEGFR3, FGFR1, FGFR2 and PDGFRα had slightly weaker effects. Phase 2.
Brand: BCM
Solubility: Soluble in DMSO. Insoluble in Water.
InChi Key: BLQYVHBZHAISJM-CMDGGOBGSA-N
Attribute [CAS No.] 934353-76-1 [Formula] C21H25N7 [Molecular] 525.56 [Chem Name] (E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine [Synonym] ENMD2076; ENMD 2076; ENMD-2076 [MDL No.] MFCD16619371 [Form] White solid powder
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