BTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM.

 

Brand: BCM

 

Target: BTK

 

Signaling Pathways: Angiogenesis; Tyrosine Kinase/Adaptors

 

pKa: 11.00±0.50(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

Isomeric SMILES: CC(C)(C)C1=NC(=NO1)C(=O)NCC2=C(C=C(C=C2)C3=C4C=C(NC4=NC=N3)C5=CN(N=C5)C)F  

 

InChIKey: XRNHJQXCSOAXLV-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H23FN8O2/c1-24(2,3)23-31-21(32-35-23)22(34)26-9-14-6-5-13(7-17(14)25)19-16-8-18(15-10-29-33(4)11-15)30-20(16)28-12-27-19/h5-8,10-12H,9H2,1-4H3,(H,26,34)(H,27,28,30) 

 

Attribute
[CAS No.]	2230724-66-8
[Formula]	C24H23FN8O2
[Molecular]	474.49
[Storage]	Sealed in dry. Stored at -20°C.
[MDL No.]	MFCD32876175
[Form]	Solid powder
[Chem Name]	5-tert-butyl-N-[[2-fluoro-4-[6-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]methyl]-1,2,4-oxadiazole-3-carboxamide
[Synonym]	Compound 27; BTK inhibitor 1

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