Berbamine (BA, BBM) dihydrochloride is a dibenzyl isoquinoline natural product isolated from the Chinese herb alamite. It is a novel inhibitor of bcr/abl with potent anti-leukemia activity and is an inhibitor of NF-κB. Berbamine (BA, BBM) dihydrochloride inhibits the growth of cancer cells and induces apoptosis in human myeloma cells by targeting Ca² + /calmodulin-dependent protein kinase II (CaMKII).

 

Brand: BCM

 

Target: Apoptosis; NF-κB; Bcr-Abl; Autophagy

 

Signaling Pathways: Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; NF-κB; Tyrosine Kinase/Adaptors

 

Melting Point: 250-253 °C(lit.)

 

Optical Activity: [α]20/D +116°, c = 1% in ethanol

 

Solubility: Soluble in DMSO; soluble in Water. Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@@H]6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC.Cl.Cl  

 

InChIKey: USRXDYNDPPUBSG-KKXMJGKMSA-N  

 

InChI: InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33;;/h6-11,18-21,28-29,40H,12-17H2,1-5H3;2*1H/t28-,29+;;/m0../s1

 

Attribute
[CAS No.]	6078-17-7
[Formula]	C37H40N2O6.2HCl
[Molecular]	665.65
[Chem Name]	(1S,14R)-20,21,25-trimethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaen-9-ol;dihydrochloride
[Synonym]	Berbamine (dihydrochloride); BA; BBM; Berbamine dihydrochloride
[Risk Codes]	Solid
[Storage]	Inert atmosphere. Room Temperature
[MDL No.]	MFCD11982910

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