Pyrotinib dimaleate is a potent, selective and irreversible dual tyrosine kinase inhibitor of EGFR and HER2 with corresponding IC50 values of 0.013 μM and 0.038 μM, respectively.

 

Brand: BCM

 

Solubility: Soluble in DMSO; Soluble in Water; Soluble in Ethanol.

 

Isomeric SMILES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/[C@H]5CCCN5C

 

InChIKey: SADXACCFNXBCFY-IYNHSRRRSA-N

 

InChI: InChI=1S/C32H31ClN6O3/c1-3-41-30-17-27-25(16-28(30)38-31(40)12-10-24-8-6-14-39(24)2)32(21(18-34)19-36-27)37-22-9-11-29(26(33)15-22)42-20-23-7-4-5-13-35-23/h4-5,7,9-13,15-17,19,24H,3,6,8,14,20H2,1-2H3,(H,36,37)(H,38,40)/b12-10+/t24-/m1/s1

 

Attribute
[CAS No.]	1269662-73-8
[Formula]	C32H31ClN6O3
[Molecular]	583.089
[Chem Name]	(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide
[Storage]	Keep in dark place. Sealed in dry, 2-8°C
[Synonym]	Pyrotinib; SHR-1258
[Form]	Powder

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