2-Methoxyestradiol (2-MeOE2, NSC 659853, NSC 659853, 2-ME2) depolymerizes microtubules and inhibits HIF-1α accumulation and HIF transcriptional activity. 2-Methoxyestradiol can induce autophagy and apoptosis in various carcinogenic cell lines.

 

Brand: BCM

 

Target: HIF; Microtubule Associated; Endogenous Metabolite; Apoptosis; Reactive Oxygen Species; Autophagy

 

Signaling Pathways: Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB

 

Melting Point: 188-190°C

 

pKa: 10.29±0.60(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS06, GHS08, GHS09

 

Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=CC(=C(C=C34)OC)O  

 

InChIKey: CQOQDQWUFQDJMK-SSTWWWIQSA-N  

 

InChI: InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1

 

Attribute
[CAS No.]	362-07-2
[Formula]	C19H26O3
[Molecular]	302.41
[Chem Name]	(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
[Storage]	Inert atmosphere. Room Temperature
[Synonym]	2-Methoxyestradiol; 2-MeOE2; NSC 659853; 2-ME2
[Form]	Light yellow to off-white solid
[MDL No.]	MFCD00010489

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