G-749 is a novel and effective FLT3 inhibitor, with IC50 values of 0.4 nM,0.6nM and 1nM for FLT3(WT),FLT3(D835Y), and Mer, respectively, with low effect on other tyrosine kinases.

In MV4-11 xenograft mice, G-749 (30 mg/kg p.o.) effectively inhibits the FLT3 pathway and significant inhibits tumor growth. In an orthogonal model of bone marrow engraftment using Molm-14 cells, G-749 (20 mg/kg p.o.) also inhibits tumor growth and increases survival.

 

Brand: BCM

 

pKa: 8.32±0.40(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water and Ethanol.

 

Attribute
[CAS No.]	1457983-28-6
[Formula]	C25H25BrN6O2
[Molecular]	521.41
[Chem Name]	Pyrido[4,3-d]pyrimidin-5(6H)-one, 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]-
[Synonym]	G-749
[MDL No.]	MFCD28167815
[Form]	Solid

Goods Tag