Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitors, which also inhibit Bcr/Abl, are also an JAK2 sensor (does not affect the 20S proteasome) and transcriptional activator (STAT). Degrasyn (WP1130) can induce apoptosis and inhibit autophagy.

 

Brand: BCM

 

Target: Autophagy; Apoptosis; JAK; DUB; Bcr-Abl

 

Signaling Pathways: Stem Cells; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors; Angiogenesis; JAK/STAT signaling; Chromatin/Epigenetic; DNA Damage/DNA Repair; Apoptosis; Ubiquitination; Cytoskeletal Signaling

 

Boiling Point: 582.1±50.0 °C at 760 mmHg

 

Flashing Point: 305.9±30.1 °C

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water. 

 

GHS: GHS07

 

Isomeric SMILES: CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N  

 

InChIKey: LIDOPKHSVQTSJY-VMEIHUARSA-N  

 

InChI: InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1

 

Attribute
[CAS No.]	856243-80-6
[Formula]	C19H18BrN3O
[Molecular]	384.27
[Chem Name]	(E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylbutyl]prop-2-enamide
[Storage]	Inert atmosphere. Store in freezer, under -20°C
[Synonym]	Degrasyn; WP1130; WP-1130
[EINECS]	604-604-1
[MDL No.]	MFCD18839228
[Form]	Yellow solid

Goods Tag