Fisogatinib (BLU-554) is a potent, highly selective, orally active FGFR4 inhibitor with an IC50 of 5 nM. The IC50 range for FGFR1-3 is 624-2203 nM.

 

Brand: BCM

 

Target: FGFR

 

Signaling Pathways: Angiogenesis; Tyrosine Kinase/Adaptors

 

In Vitro: BLU-554 exploits a unique interaction with FGFR4 to confer potency and selectivity

 

pKa: 13.77±0.40(Predicted)

 

Solubility: Soluble in DMSO; soluble in Ethanol. Insoluble in Water.

 

Isomeric SMILES: COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)N[C@@H]4COCC[C@@H]4NC(=O)C=C)Cl)OC  

 

InChIKey: MGZKYOAQVGSSGC-DLBZAZTESA-N  

 

InChI: InChI=1S/C24H24Cl2N4O4/c1-4-20(31)28-16-7-8-34-12-17(16)30-24-27-11-14-9-13(5-6-15(14)29-24)21-22(25)18(32-2)10-19(33-3)23(21)26/h4-6,9-11,16-17H,1,7-8,12H2,2-3H3,(H,28,31)(H,27,29,30)/t16-,17+/m0/s1

 

Attribute
[CAS No.]	1707289-21-1
[Formula]	C24H24Cl2N4O4
[Molecular]	503.38
[Chem Name]	N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide
[Synonym]	BLU-554; BLU554; Fisogatinib
[MDL No.]	MFCD30496704
[Form]	A crystalline solid
[Storage]	Keep in dark place. Inert atmosphere, 2-8°C

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