Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.

 

Brand: BCM

 

Target: Dehydrogenase; Sirtuin; Autophagy

 

Signaling Pathways: Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism

 

In Vitro: Tenovin-6 is a better water-soluble analogue of tenovin-1. Tenovin-6 acts by inhibiting the protein deacetyl activity of SirT1 and SirT2. Tenovin-6 inhibited the in vitro activity of purified human SIRT1, SIRT2, and SIRT3 protein deacetylases with an IC50 of 21 μM, 10 μM, and 67 μM, respectively.

 

In Vivo: Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice.

 

pKa: 9.11±0.70(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Water. Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C  

 

InChIKey: BVJSXSQRIUSRCO-UHFFFAOYSA-N  

 

InChI: InChI=1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32)

 

Attribute
[CAS No.]	1011557-82-6
[Formula]	C25H34N4O2S
[Molecular]	454.63
[Chem Name]	4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
[Storage]	Sealed in dry, 2-8°C
[Synonym]	Benzamide; Tenovin-6
[EINECS]	200-256-5
[MDL No.]	MFCD11976906
[Form]	Solid

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