MIK665 (S64315) is an inhibitor of Mcl with a Ki value of 1.2 nM. It has potential pro-apoptotic and anti-tumor activities.

 

Brand: BCM

 

Target: BCL

 

Signaling Pathways: Apoptosis

 

In Vitro: MIK665 (S-64315) had a synergistic effect when combined with ABT-199. Combined treatment with S64315 (0.156-10 μM) and ABT-199 (625 nM) reduced the cell viability of MB2141, MB3616, MB3961, MB4667, A375 and 1205Lu cells. The IC50 of MIK665 interaction with H929 cells was 250 nM.

 

Boiling Point: 909.4±65.0 °C(Predicted)

 

pKa: 2.53±0.11(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CC1=C(C=CC(=C1Cl)OCCN2CCN(CC2)C)C3=C(SC4=NC=NC(=C34)O[C@H](CC5=CC=CC=C5OCC6=NC(=NC=C6)C7=CC=CC=C7OC)C(=O)O)C8=CC=C(C=C8)F  

 

InChIKey: PKYIMGFMRFVOMB-LDLOPFEMSA-N  

 

InChI: InChI=1S/C47H44ClFN6O6S/c1-29-34(16-17-38(42(29)48)59-25-24-55-22-20-54(2)21-23-55)40-41-45(51-28-52-46(41)62-43(40)30-12-14-32(49)15-13-30)61-39(47(56)57)26-31-8-4-6-10-36(31)60-27-33-18-19-50-44(53-33)35-9-5-7-11-37(35)58-3/h4-19,28,39H,20-27H2,1-3H3,(H,56,57)/t39-/m1/s1

 

Attribute
[CAS No.]	1799631-75-6
[Formula]	C47H44ClFN6O6S
[Molecular]	875.41
[Chem Name]	(2R)-2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid
[Storage]	Sealed in dry. Store in freezer, under -20°C
[Synonym]	MIK665; S64315
[MDL No.]	MFCD32669779
[Form]	A solid

Goods Tag