Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable,  Necrostatin 1S), a stable variant of Necrostatin 1, is a more specific inhibitor of RIPK1 that does not target IDO and is more than 1,000 times more selective to RIPK1 than 485 other human kinases.

 

Brand: BCM

 

Target: RIP kinase

 

Signaling Pathways: Apoptosis; NF-κB

 

Melting Point: 173-175℃

 

pKa: 8.48±0.70(Predicted)

 

Solubility: Soluble in DMSO; Soluble in Ethanol. Insoluble in Water.

 

GHS: GHS07

 

Isomeric SMILES: CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl  

 

InChIKey: WIKGAEMMNQTUGL-UHFFFAOYSA-N  

 

InChI: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19) 

 

Attribute
[CAS No.]	852391-15-2
[Formula]	C13H12ClN3O2
[Molecular]	277.70628
[Chem Name]	5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
[Storage]	Sealed in dry. Room Temperature
[Synonym]	Nec-1s; 7-Cl-O-Nec1; 7-Cl-O-Nec1
[MDL No.]	MFCD19443135
[Form]	Off-white to pale yellow solid

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