PHA-680632 is A potent inhibitor of Aurora A, Aurora B, and Aurora C with IC50 of 27 nM, 135 nM, and 120 nM, respectively, compared to those used in FGFR1, FLT3, LCK, PLK1, STLK2, And VEGFR2/3 have IC50 values that are 10 to 200 times higher.

 

Brand: BCM

 

Target: FGFR; PLK; Aurora Kinase

 

Signaling Pathways: Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors

 

Melting Point: 240-242 °C

 

Boiling Point: 709.0±60.0 °C(Predicted)

 

pKa: 12.26±0.70(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C  

 

InChIKey: OBWNXGOQPLDDPS-UHFFFAOYSA-N  

 

InChI: InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H,4-5,13-18H2,1-3H3,(H,29,37)(H2,30,31,32,36) 

 

Attribute
[CAS No.]	398493-79-3
[Formula]	C28H35N7O2
[Molecular]	501.62
[Chem Name]	N-(2,6-diethylphenyl)-3-[[4-(4-methylpiperazin-1-yl)benzoyl]amino]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide
[Synonym]	PHA-680632; PHA680632
[Storage]	Keep in dark place. Inert atmosphere. Room temperature
[MDL No.]	MFCD16038900
[Form]	Solid powder

Goods Tag