ON123300 is a potent multi-target kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5/NUAK1, PDGFRβ, FGFR1, RET (c-RET) and Fyn, respectively.

 

Brand: BCM

 

Target: c-RET; AMPK; FGFR; Src; JAK; CDK; PDGFR

 

Signaling Pathways: Cell Cycle/Checkpoint; Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling; Apoptosis; Chromatin/Epigenetic; Stem Cells; PI3K/Akt/mTOR signaling

 

Boiling Point: 642.7±65.0 °C(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insoluble in Ethanol.

 

pKa: 7.88±0.42(Predicted)

 

GHS: GHS07

 

Isomeric SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C=C(C(=O)N(C4=N3)C5CCCC5)C#N  

 

InChIKey: VADOZMZXXRBXNY-UHFFFAOYSA-N  

 

InChI: InChI=1S/C24H27N7O/c1-29-10-12-30(13-11-29)20-8-6-19(7-9-20)27-24-26-16-18-14-17(15-25)23(32)31(22(18)28-24)21-4-2-3-5-21/h6-9,14,16,21H,2-5,10-13H2,1H3,(H,26,27,28)

 

Attribute
[CAS No.]	1357470-29-1
[Formula]	C24H27N7O
[Molecular]	429.52
[Chem Name]	8-cyclopentyl-2-[4-(4-methylpiperazin-1-yl)anilino]-7-oxopyrido[2,3-d]pyrimidine-6-carbonitrile
[Synonym]	bdbm50447512; ON123300
[Storage]	Keep in dark place. Inert atmosphere. Room temperature
[MDL No.]	MFCD28411414
[Form]	Solid

Goods Tag