Netarsudil (AR-13324) is a ROCK inhibitor with a Ki value of 0.2-10.3 nM. It is currently in clinical trials for glaucoma and ocular hypertension.

 

Brand: BCM

 

Target: ROCK

 

Signaling Pathways: Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells

 

In Vivo: Netarsudil Dihydrochloride (AR-13324 Dihydrochloride; 0.04%, 50 ΜL)reduces intraocular pressure (IOP) in normotensive monkey eyes. Netarsudil Dihydrochloride (0.04%) produces a statistically significant lowering of episcleral venous pressure (EVP) in Dutch Belted rabbits.

 

Solubility: Soluble in DMSO. Insoluble in Water; Insoluble in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)[C@@H](CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.Cl.Cl  

 

InChIKey: LDKTYVXXYUJVJM-FBHGDYMESA-N  

 

InChI: InChI=1S/C28H27N3O3.2ClH/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24;;/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32);2*1H/t26-;;/m1../s1 

 

Attribute
[CAS No.]	1253952-02-1
[Formula]	C28H27N3O3.2HCl
[Molecular]	526.45
[Chem Name]	[4-[(2S)-3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate;dihydrochloride
[Synonym]	Netarsudil (AR-13324) 2HCl; AR-13324 Dihydrochloride
[Storage]	Inert atmosphere. Room Temperature
[MDL No.]	MFCD29472289
[Form]	Solid Powder

Goods Tag