MLN8054 is A potent, selective inhibitor of Aurora A with an IC50 of 4 nM in Sf9 insect cells, which is 40 times more selective against Aurora A than against Aurora B. Phase 1.

 

Brand: BCM

 

Target: Casein Kinase; Src; PKA; Aurora Kinase

 

Signaling Pathways: Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors

 

Boiling Point: 429.5±45.0 °C at 760 mmHg

 

Flashing Point: 213.5±28.7 °C

 

Vapour Pressure: 0.0±1.0 mmHg at 25°C

 

pKa: 4.18±0.10(Predicted)

 

Solubility: Soluble in DMSO. Insoluble in Water; insolubel in Ethanol.

 

GHS: GHS07

 

Isomeric SMILES: C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O  

 

InChIKey: HHFBDROWDBDFBR-UHFFFAOYSA-N  

 

InChI: InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32)

 

Attribute
[CAS No.]	869363-13-3
[Formula]	C25H15ClF2N4O2
[Molecular]	476.86
[Chem Name]	4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid
[Synonym]	MLN8054
[Storage]	Keep in dark place. Inert atmosphere. Room temperature
[EINECS]	1592732-453-0
[MDL No.]	MFCD11840561
[Form]	Solid Powder

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