CLS-PEG-MAL is a kind of heterodiactive PEG derivatives. Cholesterol is the basic substance constituting cell membrane and liposome, and is also an indispensable important substance in animal tissue cells. It not only participates in the formation of cell membrane, but also is the raw material for the synthesis of bile acids, vitamin D and steroid hormones. Cholesterol can regulate the fluidity of phospholipid bilayer membrane, reduce membrane permeability and reduce drug leakage. At the same time, the lipid membrane can maintain a certain flexibility and enhance the ability of liposome vesicles to resist changes in external conditions. And it can protect the oxidation of phospholipid. Maleimide can form stable sulfide bonds with sulfhydryl groups at pH 6.5-7.5. Peg-linked cholesterol has better water solubility, and pegylated cholesterol derivatives can be used for cell membrane imaging, liposomes, and drug delivery. Cholesterol (CLS) can be used to make liposomes to improve the cycle time of encapsulated drugs. They can also be used as non-viral transfection reagents. It is water soluble and fat soluble.

 

Brand: BCM

 

Solubility: Soluble in Water, Chloroform, Dichloromethane, DMSO.

 

Processing & Application: Attention should be paid to temperature difference, air humidity and moisture absorption when using CLS-PEG-MAL. The reaction is protected as much as possible by an inert gas.

 

Attribute
[Chem Name]	Cholesterol-PEG-Maleimide
[Synonym]	CLS-PEG-MAL; MAL-PEG-Cholesterol
[Molecular]	2000,3400,5000, other molecular weights can be customized
[Form]	White to off-white or yellowish solid, semi-solid
[Storage]	Cold chain storage at 2-8°C

Goods Tag