Name：Lorlatinib

Catalog No.：
BCM005645

CAS No.：
1454846-35-5

Formula：
C21H19FN6O2

Molecular：
406.41

EINECS：
813-704-5

Chem Name：
(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile

Synonym：
PF-06463922; Lorlatinib

MDL No.：
MFCD28144520

Form：
White to Off-White Solid Powder

Storage：
Sealed in dry. Store in freezer, under -20°C

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SKU	Specification	Brand	Prices	Stock	Cart
BCM005645-100MG	100mg, Purity:98%	BCM	$50	1	Add Cart
BCM005645-250MG	250mg, Purity:98%	BCM	$85	1	Add Cart
BCM005645-1G	1g, Purity:98%	BCM	$270	1	Add Cart

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Lorlatinib (PF-6463922) is a potent, dual ALK/ROS1 inhibitor with a Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. PF-06463922 can induce apoptosis. Phase 1.

Brand: BCM

Target: Apoptosis; Tyrosine Kinases; ROS; ALK; ROS Kinase

Signaling Pathways: Angiogenesis; Apoptosis; Immunology/Inflammation; Tyrosine Kinase/Adaptors

Melting Point: 184-187°C

Boiling Point: 675.0±55.0 °C(Predicted)

pKa: 6.05±0.40(Predicted)

Solubility: Soluble in DMSO (warmed with 50ºC water bath); soluble Ethanol (warmed with 50ºC water bath). Insoluble in Water.

Stability: Hygroscopic

GHS: GHS08

Isomeric SMILES: C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

InChIKey: IIXWYSCJSQVBQM-LLVKDONJSA-N

InChI: InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1

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[CAS No.] 1454846-35-5

[Formula] C21H19FN6O2

[Molecular] 406.41

[EINECS] 813-704-5

[Chem Name] (16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile

[Synonym] PF-06463922; Lorlatinib

[MDL No.] MFCD28144520

[Form] White to Off-White Solid Powder

[Storage] Sealed in dry. Store in freezer, under -20°C

Attribute
[CAS No.]	1454846-35-5
[Formula]	C21H19FN6O2
[Molecular]	406.41
[EINECS]	813-704-5
[Chem Name]	(16R)-19-amino-13-fluoro-4,8,16-trimethyl-9-oxo-17-oxa-4,5,8,20-tetrazatetracyclo[16.3.1.02,6.010,15]docosa-1(22),2,5,10(15),11,13,18,20-octaene-3-carbonitrile
[Synonym]	PF-06463922; Lorlatinib
[MDL No.]	MFCD28144520
[Form]	White to Off-White Solid Powder
[Storage]	Sealed in dry. Store in freezer, under -20°C