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Tucatinib (Irbinitinib, ONT-380, ARRY-380) is an orally active, reversible, ATP-competitive small molecule inhibitor of ErbB2 (HER2). In cell experiments, the IC50s of ARY-380 against ErbB-2 and p95 HER2 were 8 nM and 7 nM respectively, and the selectivity for HER2 was 500 times greater than that for EGFR. It has potential antitumor activity.
Brand: BCM
pKa: 6.61±0.70(Predicted)
Solubility (25°C): Soluble in DMSO, insoluble in water and ethanol.
Heavy metals: ≤ 20ppm
Attribute [Chem Name] Tucatinib [Synonym] Irbinitinib, ONT-380, ARRY-380 [CAS No.] 937263-43-9 [EINECS] 200-001-8 [MDL No.] MFCD22380467 [Formula] C26H24N8O2 [Molecular] 480.52 [Form] White to light yellow powder [Risk Codes] GHS07
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