Amperozide hydrochloride is an atypical antipsychotic which displays a high affinity for 5-HT2 receptors (Ki = 26 nM) and a low affinity for D2 receptors. Amperozide hydrochloride supresses ethanol drinking in genetically ethanol-preferring rats.

 

Brand: BCM

 

Solubility: Soluble in water (50 mM).

 

Refractive Index: n20D 1.55 (Predicted)

 

IC50: Plasmodium falciparum 3D7 infected in RBCs: IC50 = 35 nM; Plasmodium falciparum: IC50 = 0.32 µM; FAAH: IC50 = 0.46 µM (human); Plasmodium falciparum HB3 : IC50 = 0.79 µM; Plasmodium falciparum 7G8: IC50 = 1.26 µM

 

Ki Data: 5-HT receptors: Ki= 26 nM

 

Isomeric SMILES: CCNC(=O)N1CCN(CC1)CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F.Cl  

 

InChIKey: OEQHKNWFXHBJIT-UHFFFAOYSA-N  

 

InChI: InChI=1S/C23H29F2N3O.ClH/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19;/h5-12,22H,2-4,13-17H2,1H3,(H,26,29);1H

 

Attribute
[Chem Name]	4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide,hydrochloride
[Synonym]	Amperozide hydrochloride
[CAS No.]	86725-37-3
[MDL No.]	MFCD04039994
[Formula]	C23H30ClF2N3O
[Molecular]	437.95400
[Form]	Solid
[Risk Codes]	Store at 4° C

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