Lincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.

 

Melting Point: 228-231 °C

 

Solubility: Soluble in DMSO. Insoluble in water.

 

Attribute
[Chem Name]	Incyclinide
[Synonym]	CMT-3; CMT 3; CMT3; COL3; COL-3; COL 3
[CAS No.]	15866-90-7
[MDL No.]	MFCD09970644
[Formula]	C19H17NO7
[Molecular]	371.34
[Form]	Yellow solid powder
[Storage]	Store lyophilized at -20ºC, keep desiccated.

Goods Tag