GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor (IC50 values of 4.1). GA-017 also enhances the ex vivo formation of mouse intestinal organoids. GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2, which phosphorylate Yes-associated protein and transcriptional coactivator with PDZ-binding motif , key effectors of the growth- and proliferation-regulating Hippo signaling pathway. GA-017 facilitates the growth of spheroids and organoids by stabilizing and translocating Yes-associated protein and transcriptional coactivator with PDZ-binding motif into the cell nucleus.

 

Brand: BCM

 

Solubility: Soluble in DMSO: 20.83 mg/mL

 

Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.

 

InChi Key: FBCPIOAXERAOIA-HKWRFOASSA-N

 

Attribute
[Chem Name]	Hydrazinecarboxamide, 2-[1-(2,4-dihydroxy-3-methylphenyl)propylidene]-N-[(3-hydroxyphenyl)methyl]-
[Synonym]	GA-017; GA 017; GA017;
[CAS No.]	2351906-74-4
[Molecular]	343.38
[Storage]	-20°C
[Formula]	C18H21N3O4

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