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JDQ443 is an effective, potent, orally active, and bioavailable GDP-bound KRASG12C covalent inhibitor with an IC50 of 0.012 µm against c-Raf.
Solubility: Soluble in DMSO and Ethanol. Insoluble in Water.
Attribute [Chem Name] 2-Propen-1-one, 1-[6-[(4R)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]- [Synonym] JDQ443; NVP-JDQ443 [CAS No.] 2653994-08-0 [MDL No.] MFCD34578463 [Formula] C29H28ClN7O [Molecular] 526.04
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