BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 demonstrated superior anti-proliferative activity to the two currently reported TACC3 inhibitors, especially in aggressive breast cancer subtypes, basal and HER2+, via spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis, while the cytotoxicity against normal breast cells was negligible.

 

Brand: BCM

 

Solubility: Soluble in DMSO

 

Shelf Life: >3 years if stored properly

 

Drug Formulation: This drug may be formulated in DMSO

 

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

 

HS Tariff Code: 2934.99.9001

 

Attribute
[Chem Name]	3-(4-methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine
[Synonym]	BO-264; BO 264; BO264
[CAS No.]	2408648-20-2
[Formula]	2408648-20-2
[Molecular]	353.38
[Form]	Solid powder

Goods Tag