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SIS3 is a cell osmotic inhibitor of Smad3, selectively inhibiting TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cell signaling. SIS3 reduces TGF-β1-induced procollagen type 1 expression and myofibroblast differentiation in normal dermal fibroblasts and scleroderma fibroblasts.
Brand: BCM
Solubility: Soluble in DMSO and Ethanol. Insoluble in Water.
InChi Key: JGYPXYFVARTDSW-ASTDGNLGSA-N
Attribute [Chem Name] Smad3 Inhibitor, SIS3 [Synonym] Smad3 Inhibitor, SIS3 [CAS No.] 1009104-85-1 [MDL No.] MFCD24368989 [Formula] C28H27N3O3 [Molecular] 453.53 [Form] Solid powder
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